Medicines and vaccines against COVID-19 you cannot create without laboratory tests. Tests on volunteers is, in fact, the final complex production chains. The first blow of taking on laboratory mice. The more common is in the experimental rodents with a man, the sooner will appear the right drug. Price humanized mice can reach ten thousand dollars per individual.
In one of the best vivariums of the country, thousands of laboratory mice grown in perfectly sterile conditions. Each population has its own mission. Below on the example of rodents to learn how diseases affect the human body, their DNA, scientists literally re-programmed.
Now at the Institute of Cytology and genetics create a so-called humanized mice. They will get sick with coronavirus with the same symptoms as people. The first offspring will be available in June, and while in the tubes to form an artificial gene, and transplanted to laboratory mice.
DNA Molecule with the gene of a person to receive in vitro — it takes two weeks. After the scientists took the mice oocytes, fertilize them and produce under the microscope microinjection — add previously obtained in the laboratory of DNA in the nucleus. After that, the embryo is returned to the body of the mouse, which twenty days will give the desired offspring. Eventually this population will be able to test vaccines and antiviral drugs.
Here at the Institute are now studying new methods of treatment of coronavirus. The first results are already there.
Scientists have proved: to stop the rapid spread of the virus in the body can drugs against rheumatoid arthritis, they are already applied. But this work is not stop to develop fundamentally new drugs on the basis of interferon. This drug will be tested on specially bred mice.
Mice from Novosibirsk are waiting for now in many laboratories of the country. The humanized mouse is a rare and Dorogoi the commodity in the international biotechnology market. Prices reach ten thousand dollars per individual, and display such animals are capable of only a few countries in the world. Experiments allow scientists to them much faster to obtain the results of their research.
by the autumn of scientists from Novosibirsk are planning to bring the required number of mice to conduct uninterrupted research in Russian labs.
